Cancer treatments may also cause skin changes. Some of these changes include dryness, redness, itching, pain or discomfort, discoloration, possibly darkening of the skin (hyperpigmentation), increased sensitivity to sunlight, or rashes. This may occur with specific chemotherapy and biotherapy treatments. Talk with your health care team to learn what side effects your treatment may cause. While skin problems caused by radiation therapy and chemotherapy are often mild, they may be more severe if you are receiving a stem cell transplant, targeted therapy, or immunotherapy. Let your health care team know if you notice any skin changes so they can be treated promptly.